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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Triamterene
supplement:
Folate
Research Papers that Mention the Interaction
“The diuretic drug triamterene has previously been shown to be a competitive inhibitor of folate absorption in the rat intestine (J Lab Clin Med 1986;108:272-6).”
Chronic diuretic therapy with moderate doses of triamterene is not associated with folate deficiency.“Kinetic analysis using the … method demonstrated that triamterene is a … of intestinal folate transport, with a Ki of 0.125 mmol/L. Because therapeutic doses can result in luminal concentration of … drug approximating or exceeding the Ki, the interaction between triamterene and folate absorption is potentially of clinical interest.”
Competitive inhibition of folic acid absorption in rat jejunum by triamterene.
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