Possible Interaction: Triamcinolone and Adrenocorticotropic Hormone

“1 day following IVTA , the peak response to ACTH at 30 min was blunted in four patients (14.3 % of the study group, p = 0.05) and the cortisol response at 60 min was suppressed (p = 0.009).”

“ Serum ACTH and 12-hour urine cortisol levels were lower 2 days after surgery in the TA group, although these changes were not statistically significant.”

“HDL1-cholesterol concentration in serum was significantly (P less than 0.001) lowered from 69 +/- 13 mg/dl (mean +/- S.D.) in triamcinolone-treated rats to 36 +/- 4 mg/dl by the administration of ACTH plus triamcinolone.”

“The additional administration of ACTH in triamcinolone-treated rats caused a slight, but significant, decrease in cholesterol concentration in apolipoprotein B-containing lipoproteins; however, HDL2-cholesterol level was not significantly affected, although there was a tendency for it to be lowered.”

“When ACTH was administered in combination with triamcinolone , the concentrations of all serum lipids except triacylglycerol were significantly lowered compared with rats treated with triamcinolone alone.”

“In spite of … glucocorticosteroids such as triamcinolone and … of corticotrophin under highly »stressful« conditions, e. g. severe haemorrhage or abdominal surgery, it has been shown that ether anaesthesia as well … or intravenous route do not result in a measurable corticotrophin release in dexamethasone pretreated rats (Hedner 8c Rerup 1962).”