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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tretinoin
drug:
Vorinostat
Research Papers that Mention the Interaction
“ Vorinostat combined with retinoids produces additive antitumor effects in preclinical studies of neuroblastoma.”
Phase I study of vorinostat in combination with isotretinoin in patients with refractory/recurrent neuroblastoma: A new approaches to Neuroblastoma Therapy (NANT) trial“A similar trend was observed for the combination of ATRA plus SAHA.”
“We found that the combination … (CI-994, MS-275, SAHA, … retinoids all-trans-retinoic acid (ATRA) or 13-cis-retinoic acid (13-CRA) or our atypical retinoic acid metabolism blocking agents (RAMBAs) …-1) or 2 (VN/66-1) produced synergistic anti-neoplastic activity on human LNCaP prostate cancer cells.”
“We demonstrate that ATRA protects APL cells from cytotoxic effects of SAHA , MS-275, and Marbostat-100.”
“Addition of subtoxic concentration of all-trans-retinoic acid (ATRA) increases the efficiency of DAC + SAHA combination on viability, apoptosis induction, and ROS generation in HL-60 cells but has no effect in CML-T1 cell line.”
“However, the histone acetylase inhibitor SAHA combined with ATRA significantly reactivated RARbeta2 mRNA both in NB4 and MR2 cells with degradation of PML-RARalpha, which was associated with maturation.”
“In NB4 cells, the combination increased apoptosis, suggesting that RA , by altering gene expression, can sensitize cells to the cytotoxic effects of SAHA.”
“The IC50 of SAHA was reduced by 40% when low dose RA was added.”
Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA)
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