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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tretinoin
drug:
Voriconazole
Research Papers that Mention the Interaction
“In contrast, ΔatmA and ΔatrA populations that similarly evolved in the presence of a subinhibitory concentration of voriconazole showed an ∼5–10-fold increase when compared to the original minimal inhibitory concentration (MIC) values.”
The Influence of Genetic Stability on Aspergillus fumigatus Virulence and Azole Resistance“Concurrent use of antifungals of the triazole family (itraconazol, voriconazol ), which are also metabolized by this liver enzymatic system, inhibits ATRA metabolism and thus raises its plasmatic levels and, potentially, calcium levels as well [4].”
“We discuss a case of hypercalcemia, which we believe was due to inhibition of cytochrome P450 function by voriconizole when used concomitantly with ATRA.”
“Serum calcium levels were returned to normal within six days after stopping the combination of ATRA and voriconazole.”
The Effects of Voriconazole on Metabolism of All-Trans Retinoic Acid in the Treatment of Acute Promyelocytic Leukemia: A Case Report
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