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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Anecdotal reports suggest that using retinoids with vitamin E leads to improvements of some side effects due to isotretinoin.”
Effects of isotretinoin on serum vitamin E levels in patients with acne“Recently, it has been shown that addition of vitamin E decreased the toxicity of high‐dose retinoids.”
“The dose of retinoic acid ranged between 10 and 60 mg/m2/daily and was administered in combination with vitamin E to diminish side effects.”
“In the current study, we hypothesized that VE supplementation inhibits CYP2E1 and decreases RA catabolism, thereby preventing ethanol-induced hepatocyte hyperproliferation.”
Vitamin E supplementation does not prevent ethanol-reduced hepatic retinoic acid levels in rats.“Biochemical measurements demonstrate that, in some species, various retinoids administered in the diet, can reduce the tissue contents of several lipid-soluble compounds: vitamin K, alpha-tocopherol , cholesterol, and vitamin A itself.”
“This study explores several possible mechanisms by which dietary retinoic acid may cause the previously described reduced intestinal absorption of alpha-tocopherol.”
“The effect of retinoic acid was prevented by d-α-tocopherol acetate.”
“In rats with mesenteric lymph cannulas, dietary retinoic acid caused a reduced absorption of 3H-labeled alpha-tocopherol.”
“In this report, the possible mechanisms by which retinoic acid alters vitamin E metabolism has been investigated.”
“It was observed that rats fed a low dietary level of retinoic acid had markedly lower plasma concentrations of alpha-tocopherol than did rats fed the same amount of retinol.”
“More oxidation of alpha-tocopherol occurred during absorption in rats fed retinoic acid than in those fed retinol, as evidenced by more alpha-tocopherylquinone in the collected lymph.”
“We postulate that dietary retinoic acid reduces the intestinal absorption of alpha-tocopherol and may also promote its oxidation.”
“It has been shown that such semi-oxidized retinoids can oxidize certain amino acids and proteins, and that α-tocopherol can scavenge the cation radicals of retinol and retinoic acid.”
Scavenging of Retinoid Cation Radicals by Urate, Trolox, and α-, β-, γ-, and δ-Tocopherols
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