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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“Androgens, retinoids , glucocorticoids, estrogens and agonists of PPAR directly or indirectly impact Vitamin D signaling pathways, and vice versa.”
Interaction of nuclear receptor ligands with the Vitamin D signaling pathway in prostate cancer“In some cases RA and vitamin D can cooperate to stimulate transcription through the same HRE.”
“In various experimental systems it was shown that the activities of vitamin D analogs can be enhanced by combined application with retinoids or other biological active compounds such as cytokines and growth factors.”
“ Retinoids and vitamin D analogs were found to have synergistic inhibitory effects on tumor cell proliferation and angiogenic capability, and both agents applied simultaneously are efficacious in small doses.”
“Our study further showed that after all-trans-retinoic acid priming, AML2 expression could be augmented by vitamin D3.”
“ Retinoids and vitamin D (VD) cooperate to induce the differentiation and inhibit the proliferation of human myelomonocytic leukemia cells.”
“These results confirm that various retinoids can cooperate with VD and demonstrate that, at a whole cell level, optimal effects require the activation of both RAR and RXR receptors.”
“Both VD3 and RA also reduced [3H]leucine incorporation (VD3:30%; RA:33%; VD3 + RA:45% inhibition) in endothelin-stimulated ventriculocytes and, once again, the combination of the two was more effective than either agent used in isolation.”
“ All-trans retinoic acid also interfered with vitamin D responsiveness, but it was consistently less potent than the 9-cis isomer.”
“Maxacalcitol has been developed as a less-calcemic vitamin D analog, but even topical application of that drug can … cause hypercalcemia in patients with renal failure and creatinine levels above 1.1 mg ⁄ dL. The combination of oral retinoid with a topical … form of vitamin D can also … hypercalcemia.”
“Our data suggest that ATRA suppresses 24-hydroxylase expression through RARalpha-dependent signaling pathway and can enhance vitamin D action in suppression of cell growth.”
“The combination of other anticancer agents such as retinoids with vitamin D offers another promising therapeutic approach.”
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