Possible Interaction: Tretinoin and Troglitazone

“A synergistic inhibitory effect on osteosarcoma cell proliferation is observed between troglitazone and retinoids , as well as with the overexpression pairs of PPARγ/RARα, or PPARγ/RXRα.”

“TGZ (10(-5) M, 4 days) reversibly inhibits clonal … of MCF7 breast cancer cells and the combination of TGZ (10(-5) …) and ATRA (10(-6) M, 4 days) synergistically and irreversibly inhibits growth and induces apoptosis … MCF7 cells, associated with a dramatic decrease of their bcl-2 protein levels.”

“Further, through retinoid metabolic profiling and HPLC analysis, our study demonstrates that troglitazone augments retinoid availability in K562 cells.”

“Cotreatment of U937/NPM-RARα cells with all-trans retinoic acid (atRA) abrogated the induction of apoptosis by TG.”

“Other peroxisome proliferator activated receptor (PPAR) ligands, 15d-PGJ(2) and troglitazone (PPARgamma), Wy14,643 (PPARalpha), and PD195599 (PPARbeta) inhibited the induction of MCP-1 by RA.”

“In summary, our studies showed that troglitazone when combined with a retinoid was a moderately potent inhibitor of clonogenic growth of acute myeloid leukemia cells.”

“Simultaneous treatment of myeloid leukemia cell lines with both troglitazone and a ligand that specifically binds either RXR (LG100268), or retinoic acid receptors (RAR, ATRA , ALART1550), or both (9-cis RA) resulted in additive suppression of clonal growth.”

“The expression of PPARgamma and RXRalpha remained unchanged with the various treatments, whereas the expression of RARalpha was substantially reduced after treatment with the combination of retinoic acid and troglitazone.”