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Last Updated: 6 months ago

Possible Interaction: Tretinoin and Troglitazone

supplement:

Tretinoin

Research Papers that Mention the Interaction

A synergistic inhibitory effect on osteosarcoma cell proliferation is observed between troglitazone and retinoids , as well as with the overexpression pairs of PPARγ/RARα, or PPARγ/RXRα.
Clinical Cancer Research  •  2010  |  View Paper
TGZ (10(-5) M, 4 days) reversibly inhibits clonal … of MCF7 breast cancer cells and the combination of TGZ (10(-5) …) and ATRA (10(-6) M, 4 days) synergistically and irreversibly inhibits growth and induces apoptosis … MCF7 cells, associated with a dramatic decrease of their bcl-2 protein levels.
Proceedings of the National Academy of Sciences of the United States of America  •  1998  |  View Paper
Further, through retinoid metabolic profiling and HPLC analysis, our study demonstrates that troglitazone augments retinoid availability in K562 cells.
PloS one  •  2014  |  View Paper
Cotreatment of U937/NPM-RARα cells with all-trans retinoic acid (atRA) abrogated the induction of apoptosis by TG.
Oncogene  •  2003  |  View Paper
Other peroxisome proliferator activated receptor (PPAR) ligands, 15d-PGJ(2) and troglitazone (PPARgamma), Wy14,643 (PPARalpha), and PD195599 (PPARbeta) inhibited the induction of MCP-1 by RA.
Arteriosclerosis, thrombosis, and vascular biology  •  1999  |  View Paper
In summary, our studies showed that troglitazone when combined with a retinoid was a moderately potent inhibitor of clonogenic growth of acute myeloid leukemia cells.
Simultaneous treatment of myeloid leukemia cell lines with both troglitazone and a ligand that specifically binds either RXR (LG100268), or retinoic acid receptors (RAR, ATRA , ALART1550), or both (9-cis RA) resulted in additive suppression of clonal growth.
International journal of oncology  •  1999  |  View Paper
The expression of PPARgamma and RXRalpha remained unchanged with the various treatments, whereas the expression of RARalpha was substantially reduced after treatment with the combination of retinoic acid and troglitazone.
Journal of the National Cancer Institute  •  2000  |  View Paper