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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tretinoin
drug:
Tiazofurin
Research Papers that Mention the Interaction
“ Tiazofurin was synergistic in cytotoxicity and in causing differentiation with ribavirin, retinoic acid , and difluorodeoxycytidine.”
Role of differentiation induction in action of purine antimetabolites“ Tiazofurin and retinoic acid together in HL-60 cells provided synergistic impact on differentiation and cytotoxicity.”
“ Tiazofurin showed additivity or synergism with ribavirin, retinoic acid , taxol, quercetin, gemcitabin, dipyridamole and brefeldin.”
“Since it has been shown that tiazofurin down-regulated the expression of c-Ki-ras oncogene, and retinoic acid that of the myc oncogene, the joint impact of these drugs is of clinical interest particularly in end-stage leukemia where the therapeutic usefulness of tiazofurin has recently been demonstrated.”
“ Tiazofurin and retinoic acid synergistically induced differentiation and inhibited colony formation in HL-60 human promyelocytic leukemia cells in cell culture.”
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