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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Tretinoin and Sphingosine 1-Phosphate

supplement:

Tretinoin

Research Papers that Mention the Interaction

Conclusions/Significance In the presence of functional RARα, RA inhibits cell growth by concertedly, and inversely, modulating the CER and S1P synthetic pathways.
PloS one  •  2007  |  View Paper
Our previous study showed that S1P antagonized the effects of all-trans-retinoic acid (ATRA) via the receptor-dependent and independent pathway.
S1P antagonized the effect of ATRA on HT-29 cell proliferation, the ATRA-induced RARβ expression, the arrest of cell cycle in G1-phase, and induction of apoptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2014  |  View Paper
Decreasing S1P production or inhibiting SphK2 activity could enhance the efficacy of retinoids in cancer treatments.
S1P antagonized ATRA activity on HT-29 cell proliferation and retinoic acid receptor beta (RARβ) expression.
Cancer letters  •  2012  |  View Paper
In addition, SPP markedly stimulated transient chloramphenicol acetyltransferase (CAT) activity of retinoic acid-dependent transcriptional activity in the cells transfected with a DR-5-CAT reporter gene.
The Journal of biological chemistry  •  2000  |  View Paper