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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tretinoin
supplement:
Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“Conclusions/Significance In the presence of functional RARα, RA inhibits cell growth by concertedly, and inversely, modulating the CER and S1P synthetic pathways.”
Disruption of Retinoic Acid Receptor Alpha Reveals the Growth Promoter Face of Retinoic Acid“Our previous study showed that S1P antagonized the effects of all-trans-retinoic acid (ATRA) via the receptor-dependent and independent pathway.”
“ S1P antagonized the effect of ATRA on HT-29 cell proliferation, the ATRA-induced RARβ expression, the arrest of cell cycle in G1-phase, and induction of apoptosis.”
“Decreasing S1P production or inhibiting SphK2 activity could enhance the efficacy of retinoids in cancer treatments.”
“ S1P antagonized ATRA activity on HT-29 cell proliferation and retinoic acid receptor beta (RARβ) expression.”
“In addition, SPP markedly stimulated transient chloramphenicol acetyltransferase (CAT) activity of retinoic acid-dependent transcriptional activity in the cells transfected with a DR-5-CAT reporter gene.”
Selective stimulation by ceramide of the expression of the alpha isoform of retinoic acid and retinoid X receptors in osteoblastic cells. A role of sphingosine 1-phosphate-mediated AP-1 in the ligand-dependent transcriptional activity of these receptors.
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