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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Tretinoin
drug:
Rosiglitazone
Research Papers that Mention the Interaction
“The VEGF mRNA level was further more decreased after RGZ + ATRA treatment.”
[Influence of rosiglitazone and all-trans-retinoic acid on angiogenesis and growth of myeloma xenograft in nude mice].“10 micromol/L of RGZ induced apoptosis of (9.8 +/- 1.7)% in U266 cells and (10.7 +/- 3.3)% in RPMI8226 cells, in a time and dose dependent manner and combined with ATRA intensified the apoptosis induction effects (P < 0.01 in both cell lines).”
“A combination of RGZ with ATRA could enhance the inhibition effect (P < 0.001 in U266, P < 0.01 in RPMI8226).”
“ ATRA can enhance these effects of RGZ.”
“The addition of RGZ + ATRA in the culture further decreased the levels.”
“The xenograft of U266 cells in BALB/c nude mice were inhibited by RGZ and so did more by the combination of RGZ and ATRA (P < 0.01).”
“Mechanistically, we found that the osteogenic differentiation induced by the combination of RSG and ATRA may be mediated partly by suppressing RSG-induced adipogenic differentiation and activating bone morphogenetic protein (BMP)/Smad signaling.”
“On the whole, our findings demonstrate that RSG in combination with ATRA promotes the commitment of MEFs to the osteoblast lineage.”
All-trans retinoic acid shifts rosiglitazone-induced adipogenic differentiation to osteogenic differentiation in mouse embryonic fibroblasts“The combination of ATRA + RSG caused the strongest inhibition, accompanied by decreased expression of collagen I, α-smooth muscle actin, TGFβ1, and TNFα.”
“After the combined application of RSG and ATRA , the positive rates significantly declined to only 19.33, 20.58 and 13.13%, respectively (P<0.01).”
“In conclusion, the combination of RSG and ATRA reduced the expression of COX-2, MMP-7 and TIMP-1, caused cell cycle arrest at the G1 phase and induced apoptosis, which resulted in the inhibition of cell proliferation in the HCT-15 human colorectal cancer cell line.”
“The combination of RSG and ATRA exhibited significant synergy (q>1.15).”
“The combination of RSG and ATRA resulted in even stronger G1 cell cycle arrest (P<0.05).”
Rosiglitazone and retinoic acid inhibit proliferation and induce apoptosis in the HCT-15 human colorectal cancer cell line.
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