Possible Interaction: Tretinoin and Retinyl Palmitate

“Based on an intention-to-treat analysis, results obtained using linear mixed models showed that supplementation with retinyl palmitate statistically significantly increased concentrations of all three RA isomers from baseline levels.”

“Our investigation was conducted to determine whether vitamin A retinyl palmitate ) supplementation significantly increases circulating RA concentrations of all-trans-, 9-cis-, and 13-cis-RA.”

“As the most common form of vitamin A taken for dietary supplementation, retinyl palmitate binds to and activates retinoid receptors, thereby inducing cell differentiation and decreasing cell proliferation.”

“Both BC and RE supplementation increased retinoic acid mediated transcriptional responses in intestine (on Isx and Bco1) and the liver (on Cyp26a1 and Cpt1a).”

“We have demonstrated that micromolar concentrations of HPR, retinoic acid , 13-cis-retinoic acid or Acitretin significantly reduced the in vitro hydrolysis of retinyl palmitate.”

“After administering … mumoles retinyl palmitate, retinoids increased four-fold in blood leukocytes after 5 h. There was almost no difference in retinoid uptake in leukocytes in Watanabe Heritable … rabbits, suggesting that chylomicron remnant retinyl esters are taken up in peripheral blood leukocytes independently of the low density lipoprotein receptor.”

“We discuss the possible relationship between liver retinyl palmitate levels and availability of retinoic acid to support immune function.”

“This finding suggests that the preventive effect of RoP is weaker than that of other retinoids showing approximately the same degree of prevention.”