supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Tretinoin
Research Papers that Mention the Interaction
“Antiproliferative studies in vitro suggested that the growth of three human breast carcinomas (MCF-7, MDA-MB-231, and MDA-MB-468), … carcinoma (NIH-OVCAR-3), and a malignant melanoma (SK-MEL-1) was inhibited to a greater degree by combination treatment with human IFN-beta … RA compared … agents.”
“Established, 6-week-old NIH-OVCAR-3 tumors underwent regression when treated with the combination of IFN-beta and RA but not with single-agent therapy.”
“Sequential treatment of MCF-7 cells with RA followed by IFN-beta was more effective at inhibiting growth than treatment with IFN-beta followed by RA, suggesting that RA modulated the anticellular response of IFN-beta rather than the converse.”
Synergistic antitumor effects of a combination of interferons and retinoic acid on human tumor cells in vitro and in vivo.“In combination treatment RA potentiates IFN-beta effect in SCC ME-180 but not in SiHa cell line, partially resistant to RA antiproliferative action.”
“The differentiating capacity of retinoic acid was enhanced by all the IFNs-alpha tested, and by rIFN-beta , but not rIFN-gamma.”
“These data suggest that there is a strong synergistic cell killing effect between IFN-beta and RA against the U937 cells.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback