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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Tretinoin and Recombinant Interferon Beta

Research Papers that Mention the Interaction

Antiproliferative studies in vitro suggested that the growth of three human breast carcinomas (MCF-7, MDA-MB-231, and MDA-MB-468), … carcinoma (NIH-OVCAR-3), and a malignant melanoma (SK-MEL-1) was inhibited to a greater degree by combination treatment with human IFN-beta … RA compared … agents.
Established, 6-week-old NIH-OVCAR-3 tumors underwent regression when treated with the combination of IFN-beta and RA but not with single-agent therapy.
Sequential treatment of MCF-7 cells with RA followed by IFN-beta was more effective at inhibiting growth than treatment with IFN-beta followed by RA, suggesting that RA modulated the anticellular response of IFN-beta rather than the converse.
Clinical cancer research : an official journal of the American Association for Cancer Research  •  1997  |  View Paper
In combination treatment RA potentiates IFN-beta effect in SCC ME-180 but not in SiHa cell line, partially resistant to RA antiproliferative action.
Oncogene  •  2000  |  View Paper
The differentiating capacity of retinoic acid was enhanced by all the IFNs-alpha tested, and by rIFN-beta , but not rIFN-gamma.
Journal of interferon research  •  1987  |  View Paper
These data suggest that there is a strong synergistic cell killing effect between IFN-beta and RA against the U937 cells.
Cancer research  •  1985  |  View Paper