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Last Updated: 4 years ago
supplement:
Tretinoin
Research Papers that Mention the Interaction
“In conclusion, both natural and synthetic retinoids demonstrate a significant inhibitory effect on HCG secretion by the early placenta (pre-HCG peak).”
“Inhibition of HCG secretion by retinoids may contribute either directly or indirectly to their teratogenicity.”
Gestational-age-dependent effects of retinoids on HCG secretion by placental explants.“ Retinoic acid increased the production of HCG and PSβG but inhibited the production of HCGα in these cells.”
“The retinoic acid induced phenotypic changes in these placental cells were reversible; removal of retinoic acid immediately decreased the production of HCG and PSβG while increasing the production of HCGα.”
“In these cells, RA potentiated the hCG secretion increase induced by EGF.”
“RA had no effect on cell proliferation in JAR spheroids, but 10(-5) M RA treatment induced a fivefold increase in secretion of human chorionic gonadotrophin ( hCG ), a known marker of conversion of cytotrophoblast to syncytiotrophoblast-like cells.”
“Although the proliferation of JAR cells was not inhibited by these agents, retinoic acid and TNF markedly increased both the intracellular levels as well as the secreted amounts of hCG.”
“In addition to stimulating PS beta G production, retinoic acid increased the production of hCG and its alpha-subunit (hCG alpha) by choriocarcinoma cells.”
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