Possible Interaction: Tretinoin and Polypeptides

“ RA stimulates an increase in polypeptides of 58, 60, 65, and 70 kDa with the 58- and 65-kDa species being dephosphorylated forms of the 60- and 70-kDa species.”

“The polypeptide binds with negative cooperativity, or without cooperativity to retinoic acid and thyroid response elements respectively, but with high cooperativity to the ERE.”

“Analysis of biosynthesized ALP monomers revealed that RA increased glycosylation of the polypeptides.”

“However, treatment with retinoic acid causes a decrease in IGF I and an increase in IGF II polypeptide levels.”

“In contrast, 48 h exposure to retinoic acid increased IGF II polypeptide levels, possibly due to increased levels of IGF binding protein‐6.”

“ Retinoic acid treatment for 48 h decreased IGF I polypeptide levels in the culture medium.”

“Nevertheless, retinoic acid effectively antagonized the stimulation of protein synthesis by TGF-beta and restored control levels of synthesis at 1 x 10(-7) …-acid-treated cultures, but treatment with the TGF-beta s restored these components in coincubation cultures, again supporting the antagonistic role of the polypeptide … retinoid ….”

“The treatment of nullipotent F9 cells with retinoic acid , which induces entodermal differentiation, activates the synthesis of these polypeptides.”

“ Abstract Retinoids at low concentrations strikingly enhance the growth-promoting activity of polypeptides like epidermal growth factor, insulin, vasopressin and fibroblast-derived growth factor and of 12-0-tetradecanoyl-phorbol-13-acetate, a potent tumour-promoting agent.”

“ Retinoids also show mitogenic synergism with TPA or polypeptide growth factors.”

“Seventeen polypeptides were upregulated during induction; several of these were significantly regulated 48 h after the addition of retinoic acid.”