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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Tretinoin and Perfosfamide

supplement:

Tretinoin

Research Papers that Mention the Interaction

In this study, we test the hypothesis that the accumulation of intracellular retinoic acid may lead to the suppression of ALDH expression and thus increase cytotoxicity to 4-hydroperoxycyclophosphamide (4-HC) in vitro.
These results suggest a post-translational mechanism through which retinoids decrease both ALDH expression, which results in increased cytotoxicity of 4-HC and acetaldehyde, although other previously described effects of these retinoids may contribute to the slight increase in cytotoxicity seen with other chemotherapy agents.
Journal of Pharmacology and Experimental Therapeutics  •  2005  |  View Paper