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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Tretinoin and Perfosfamide

supplement:

Tretinoin

Research Papers that Mention the Interaction

Furthermore, ATRA increases 4-HC toxicity even when added to a combination of siRNAs against both enzymes, thus suggesting additional mechanisms by which ATRA can increase drug toxicity.
On the other hand, ATRA had minimal and insignificant additional inhibitory effects on ALDH enzyme activity when added to a combination of siRNAs against both enzymes, but still increased 4-HC toxicity beyond that seen with RNAi-mediated inhibition of both enzymes together.
Cancer Chemotherapy and Pharmacology  •  2006  |  View Paper
In this study, we test the hypothesis that the accumulation of intracellular retinoic acid may lead to the suppression of ALDH expression and thus increase cytotoxicity to 4-hydroperoxycyclophosphamide (4-HC) in vitro.
These results suggest a post-translational mechanism through which retinoids decrease both ALDH expression, which results in increased cytotoxicity of 4-HC and acetaldehyde, although other previously described effects of these retinoids may contribute to the slight increase in cytotoxicity seen with other chemotherapy agents.
Journal of Pharmacology and Experimental Therapeutics  •  2005  |  View Paper