Possible Interaction: Tretinoin and Paclitaxel

“Co-delivery of all-trans-retinoic acid and paclitaxel using albumin-bound nanoparticles demonstrated a significantly improved anti-metastatic effect to breast cancer both in vitro and in vivo.”

“Their migration ability into the scaffolds' size-restricted pores, enabled by cell softening during ATRA differentiation, was significantly reduced by paclitaxel treatment, which interferes with cell shape recovery.”

“Histopathological examination revealed that ATRA induced differentiation and combination of ATRA and TXL caused more apoptosis than either treatment alone.”

“At the same time, RA could arrest the cell cycle of CSCs and reduce the expression of Sox-2, Oct-4 in CSCs of melanoma, thereby induced the differentiation of CSCs and increased its sensitivity to paclitaxel.”

“With this study we concluded that RA increases the anticancer effect of paclitaxel by inducing differentiation of cancer stem cells in melanoma, and the combined application of RA and paclitaxel may be more effective in the treatment of melanoma.”

“Using the human embryonal carcinoma cell line … that exposure to the differentiating agent retinoic acid produced a reduction in pluripotency markers NANOG and POU5F1 (Oct3/… concentration-dependent increase in resistance to both cisplatin and paclitaxel that reached as high as 18-fold … 61-fold for paclitaxel within four days.”

“Furthermore, the activity of MMP-2, a key enzyme in tumor cell invasion, was significantly decreased in cells treated with the combination of paclitaxel and ATRA while other combinations and single agents did not significantly affect its activity.”

“The results of the present study suggest that combination treatment with paclitaxel and ATRA could be an effective treatment for the inhibition of tumor cell proliferation and invasion, and that nanoparticles are promising candidates for antitumor drug delivery.”

“Retinol and β-carotene, but not retinoids , added to the culture exerted an effect on paclitaxel activity.”

“Thus, combination of retinoid and TXL could be an effective therapeutic strategy for controlling the growth of glioblastoma.”

“We hypothesized that induction of differentiation with retinoid could increase sensitivity to microtubule-binding drug taxol ( TXL ) for apoptosis in human glioblastoma T98G and U87MG cells.”

“For example, one of the in vitro studies suggests that retinoic acid may greatly increase the efficacy of cisplatin and paclitaxel (Taxol, Bristol-Myers Squibb, Princeton, NJ) against some types of ovarian cancers.”

“Results demonstrated that retinoids induced astrocytic differentiation with down regulation of telomerase activity and worked synergistically to enhance sensitivity of cells to the cytotoxic agent IFN-γ and the cytostatic agent TXL for apoptosis.”