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“We found that the … HDIs (CI-994, MS-275 , SAHA, … retinoids all-trans-retinoic acid (ATRA) or 13-cis-retinoic acid (13-CRA) or our atypical retinoic acid metabolism blocking agents (RAMBAs) …-1) or 2 (VN/66-1) produced synergistic anti-neoplastic activity on human LNCaP prostate cancer cells.”
Bioorganic & medicinal chemistry • 2008 | View Paper
“Administration of MS-275 in VPA offspring significantly elevated the levels of AcH3, ALDH1A1 mRNA and protein, ALDH activity, RA , the level of RARα protein and the binding of AcH3 to the ALDH1A1 promoter.”