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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Liarozole is an imidazole compound that inhibits enzymes involved in steroid hormone aromatisation and retinoid metabolism.”
EORTC 10941: A phase II study of liarozole in postmenopausal patients with ‘Chemotherapy-Resistant’ or ‘Potentially Hormone Sensitive’ metastatic breast cancer“On days 2 and 29, liarozole was given 1 h prior to ingestion of all-trans RA at single doses ranging from 75 to 300 mg.”
“We conclude that liarozole at a dose of 300 mg effectively attenuates the induced decline in all-trans RA plasma concentrations that occurs with continuous treatment.”
“ Liarozole is an imidazole‐like compound that inhibits the retinoic acid (RA) 4‐hydroxylase‐mediated breakdown of all‐trans RA, causing elevation of plasma and cutaneous levels of RA.”
“ Liarozole is a 1-substituted imidazole derivative that inhibits cytochrome P450 activity and increases endogenous plasma concentrations of retinoid acid (RA).”
“Background Liarozole is an inhibitor of the metabolism of all‐trans‐retinoic acid.”
“ Liarozole is a novel inhibitor of the enzyme cytochrome P450 which has inhibitory effects on the 4-hydroxylation of retinoic acid.”
“ Liarozole promotes differentiation of cancer cells by increasing the intratumoral levels of retinoic acid.”
“The imidazole derivative liarozole is a potent inhibitor of cytochrome P450‐dependent 4‐hydroxyla‐tion of endogenous all‐trans retinoic acid , thereby increasing the levels of all‐trans retinoic acid in both plasma and skin.”
“ Liarozole is an imidazole derivative that has been identified as an inhibitor of the cytochrome P450‐dependent all‐trans retinoid acid (RA) breakdown.”
“ Liarozole , a novel imidazole derivative, inhibits the cytochrome P450‐dependent 4‐hydroxylation of retinoic acid.”
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