Possible Interaction: Tretinoin and Leptin

“In conclusion, all‐trans RA reduced both expression and secretion of leptin in human and rodent adipose tissue.”

“In human adipose tissue explants, 1 μM all‐trans RA reduced leptin mRNA expression levels by 55% and leptin secretion by 25% after 24 h incubation.”

“ ATRA also modulated adipokine expression by increasing the mRNA level of adipocytokines (adiponectin, leptin and LPL), and by inhibiting PAI‐1 mRNA expression in mature AML‐I adipocytes.”

“In conclusion, in vitro leptin secretion by human adipose tissue is negatively controlled by either RA or vitamin D(3).”

“These results suggest that retinoids regulate leptin expression and highlight a role for RXRalpha in this process.”

“Recent studies have demonstrated that Lep and Lep-R expression in developing lungs is regulated by ATRA.”

“Tsuchiya et al. demonstrated that the leptin pathway may be crucial for the anti-insulin resistance action of ATRA , and we proposed PTEN as a mediator of its antisteatotic effect.”

“In in vitro experiments, ATRA significantly enhanced insulin-induced IRS1 tyrosine phosphorylation solely in the presence of leptin.”

“They also demonstrate a direct inhibitory effect of RA on leptin expression in both white and brown adipocyte cell cultures, and constitute first proof of the involvement of both RA receptors (RARs) and rexinoid receptors (RXRs) in this effect.”

“Treatment of activated stellate cells with either 1 microM retionic acid or 10 microM retinol acetate resulted in the inhibition of leptin mRNA expression.”