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Discover Supplement-Drug Interactions

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Last Updated: 4 years ago

Possible Interaction: Tretinoin and Lapatinib

supplement:

Tretinoin

Research Papers that Mention the Interaction

In estrogen-receptor-negative cellular models showing coamplification of ERBB2 and RARA, simultaneous targeting of the corresponding gene products with combinations of lapatinib and ATRA causes synergistic growth inhibition, cyto-differentiation and apoptosis.
The available cellular models were exploited to define the molecular mechanisms underlying the antitumor activity of combinations between lapatinib and ATRA.
Oncogene  •  2012  |  View Paper
In validating experiments, combination of Lapatinib and all-trans retinoic acid (ATRA) synergistically suppresses cell growth, and accompanied by decreased expression of MYC.
Front. Pharmacol.  •  2018  |  View Paper