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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Tretinoin and L-Threo-Dihydrosphingosine

Research Papers that Mention the Interaction

Sphinganine (SP) pre-treatment potentiated the retinoic acid (RA)-induced (4-96h exposures) differentiation and increase of alkaline phosphatase (ALP) activity.
Life sciences  •  1993  |  View Paper
The combination of RA and sphinganine increased in parallel the percentage of mature cells and the ALP activities.
Biochemical and biophysical research communications  •  1992  |  View Paper
In the presence of SP , PKC activity decreased more rapidly to its lowest (60% of the control) within 24h of incubation of RA.
SP , added 24h before or concomitantly with the addition of RA , could potentiate the RA-induced differentiation and the reduction of PKC activity.
Life sciences  •  1992  |  View Paper
Cells treated with sphinganine were more responsive to RA.
Differentiation, translocation of nucleophosmin, and inhibition of cell growth occurred with lesser doses of RA or in shorter incubation times in the presence of sphinganine.
Pretreatment but not posttreatment of HL-60 cells with sphinganine , however, modulated the reversibility of the effects induced by short-exposure RA treatment.
Experimental hematology  •  1992  |  View Paper