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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tretinoin
Research Papers that Mention the Interaction
“ Sphinganine (SP) pre-treatment potentiated the retinoic acid (RA)-induced (4-96h exposures) differentiation and increase of alkaline phosphatase (ALP) activity.”
Alkaline phosphatase activity during sphinganine potentiation of retinoic acid-induced differentiation of human promyelocytic leukemia cell line, HL-60.“The combination of RA and sphinganine increased in parallel the percentage of mature cells and the ALP activities.”
“In the presence of SP , PKC activity decreased more rapidly to its lowest (60% of the control) within 24h of incubation of RA.”
“ SP , added 24h before or concomitantly with the addition of RA , could potentiate the RA-induced differentiation and the reduction of PKC activity.”
“Cells treated with sphinganine were more responsive to RA.”
“Differentiation, translocation of nucleophosmin, and inhibition of cell growth occurred with lesser doses of RA or in shorter incubation times in the presence of sphinganine.”
“Pretreatment but not posttreatment of HL-60 cells with sphinganine , however, modulated the reversibility of the effects induced by short-exposure RA treatment.”
Schedule-dependent sphinganine potentiation of retinoic acid-induced differentiation, cell growth inhibition, and nucleophosmin translocation in a human leukemia cell line (HL-60).
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