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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Tretinoin
drug:
Itraconazole
Research Papers that Mention the Interaction
“Concurrent use of antifungals of the triazole family itraconazol , voriconazol), which are also metabolized by this liver enzymatic system, inhibits ATRA metabolism and thus raises its plasmatic levels and, potentially, calcium levels as well [4].”
All-trans-retinoic acid induced acute pancreatitis: a single or multifactorial association?“We present a case of hypercalcemia due to an interaction of ATRA and itraconazole treatment.”
“The results showed that among these compounds only six compounds (N-benzyl-2-phenylethanamine, itraconazole , chlorpromazine, 5-chloro-1,3-benzoxazol-2-amine, proadifen and furazolidone) showed inhibition of RA metabolism which was > 50%.”
Study on Cytochrome P-450 Dependent Retinoic Acid Metabolism and its Inhibitors as Potential Agents for Cancer Therapy
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