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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Tretinoin
drug:
Interleukin-10
Research Papers that Mention the Interaction
“Additionally, ATRA reduces the expression of immunosuppressive genes including PD‐L1, IL‐10 , and indoleamine 2,3‐dioxygenase by MDSCs.”
Targeting myeloid‐derived suppressor cells using all‐trans retinoic acid in melanoma patients treated with Ipilimumab“ ATRA therapy could significantly increase the percentage of Treg cell, IL-10 level and Foxp3 expression.”
“ ATRA treatment not only reduced pro-inflammatory cytokine responses, such as TNF-α, IL-6, IL-1β, IFN-γ and IL-17 production but also increased IL-10 response in the supernatant of intestinal tissue.”
“We show that ATRA alleviates the negative feedback loop effect of IL-10 anti-inflammatory cytokine on NLRP3 inflammasome function by inhibiting the Akt-mTOR-STAT3 signaling axis.”
“ ATRA stimulates megakaryocytopoiesis, restores concentration of regulatory T cells, and increases interleukin-10 concentrations and FOXP3 (forkhead box protein P3) expression.”
“Importantly, RA enhanced the secretion of IL-10 by MS-derived B cells without affecting the levels of the pro-inflammatory cytokine TNF-α.”
“While atRA downregulated the proinflammatory cytokines, e.g., IL-12 and TNF-α, the production of an immune modulating cytokine, IL-10 was enhanced by atRA.”
“In addition, IL-10 abolishes all trans retinoic acid (ATRA)-induced growth inhibition of myeloma cells.”
“ RA differentially modulated the expression of interleukin‐1β ( IL‐10 ), IL‐6, and IL‐8 mRNAs depending on the inducing stimulus.”
“Our data demonstrate that RA treatment enhances TLR2-dependent IL-10 production from T cells and this, in turn, potentiates T regulatory cell (TREG) generation without the need for activation of antigen presenting cells.”
Retinoic Acid Can Exacerbate T Cell Intrinsic TLR2 Activation to Promote Tolerance
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