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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tretinoin
Research Papers that Mention the Interaction
“Also, HMBA showed marked synergism with RA and 5azaC in inhibiting colony growth.”
Synergistic interactions between differentiation-inducing agents in inhibiting the proliferation of HL-60 human myeloid leukaemia cells in clonogenic micro assays“Treatment with hexamethylene bisacetamide HMBA ) combined with ATRA enhances ATRA-induced differentiation in ATRA-insensitive NB4-CI and arsenic-resistant NB4/As cells, and is associated with stabilization of PML-RARalpha protein and increased deltaPML-RARalpha formation.”
“A measure of the effectiveness of these combinations was that the concentrations of RA in combination with BA and HMBA inducing half-maximal differentiation were 20- to 40-fold lower than those needed with RA alone.”
“Pretreatment with HMBA before exposure to RA failed to stimulate differentiation.”
“Together, these results suggest that intermittent low doses of RA followed by either HMBA or butyrates may be a useful combination in the treatment of APL.”
“The addition of RA reduced the promotion of growth and increased the extent of terminal differentiation seen with HMBA and DMSO alone.”
“These data suggest that treatment of some malignancies with combinations of RA with HMBA or NaB may maintain differentiation-inducing effects and decrease the problems associated with the achievement and maintenance of effective plasma concentrations as single agents.”
“We found that combinations of RA with either NaB, HMBA , or DMSO synergistically induced terminal differentiation of HL60.”
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