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Last Updated: 2 years ago

Possible Interaction: Tretinoin and Genistein

supplement:

Tretinoin

supplement:

Genistein

Research Papers that Mention the Interaction

Further, the combined use of ATRA and genistein leads to cancer cell arrest in G0/G1 and G2/M cell cycle phases.
In conclusion, our results demonstrate that genistein effectively enhances anti-cancer effects of ATRA , particularly, by countering the ATRA-induced up-regulation of VEGF.
We hypothesized that genistein , applied simultaneously with ATRA , would counter its undesired angiogenic effects and, thus, enhance the anti-cancer effects of ATRA.
Cell Biochemistry and Biophysics  •  2011  |  View Paper
We here demonstrate that genistein causes G(2)/M cycle arrest and expression of differentiation markers in human acute myeloid leukaemia cells (HL60, NB4), and cooperates with all-trans retinoic acid (ATRA) in inducing differentiation, while ATRA attenuates the isoflavone-provoked toxicity.
Biochemical pharmacology  •  2009  |  View Paper
Finally, inhibition of EGFR activation by genistein reduces epidermal hyperplasia caused by topical retinoid treatment.
The Journal of investigative dermatology  •  2006  |  View Paper
The tyrosine kinase inhibitor genistein caused a dose-dependent inhibition of TIMP-1 protein induction by ATRA and bFGF.
European journal of biochemistry  •  2000  |  View Paper
The differentiation-inducing effect of genistein was augmented by addition of 1 alpha,25-dihydroxyvitamin D3 (VD3) or retinoic acid , VD3 being more effective than retinoic acid.
Leukemia research  •  1991  |  View Paper
In conclusion, we confirm that GEN in combination with ATRA is an effective strategy to up regulate the p14 tumor suppressor gene and induce cell apoptosis in OVCAR-3 cell line.
Research in pharmaceutical sciences  •  2016  |  View Paper