Possible Interaction: Tretinoin and Genistein

“Further, the combined use of ATRA and genistein leads to cancer cell arrest in G0/G1 and G2/M cell cycle phases.”

“In conclusion, our results demonstrate that genistein effectively enhances anti-cancer effects of ATRA , particularly, by countering the ATRA-induced up-regulation of VEGF.”

“We hypothesized that genistein , applied simultaneously with ATRA , would counter its undesired angiogenic effects and, thus, enhance the anti-cancer effects of ATRA.”

“We here demonstrate that genistein causes G(2)/M cycle arrest and expression of differentiation markers in human acute myeloid leukaemia cells (HL60, NB4), and cooperates with all-trans retinoic acid (ATRA) in inducing differentiation, while ATRA attenuates the isoflavone-provoked toxicity.”

“Finally, inhibition of EGFR activation by genistein reduces epidermal hyperplasia caused by topical retinoid treatment.”

“The tyrosine kinase inhibitor genistein caused a dose-dependent inhibition of TIMP-1 protein induction by ATRA and bFGF.”

“The differentiation-inducing effect of genistein was augmented by addition of 1 alpha,25-dihydroxyvitamin D3 (VD3) or retinoic acid , VD3 being more effective than retinoic acid.”

“In conclusion, we confirm that GEN in combination with ATRA is an effective strategy to up regulate the p14 tumor suppressor gene and induce cell apoptosis in OVCAR-3 cell line.”