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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Tretinoin and Gefitinib

supplement:

Tretinoin

Research Papers that Mention the Interaction

In addition, it remains unclear which cellular kinases are being targeted by gefitinib to elicit enhancement of ATRA action, although their elucidation may provide novel targets for therapeutic intervention in AML.
Similarly, the combination of ATRA and gefitinib resulted in enhanced induction of U937 cell differentiation, as assessed by CD11b expression analysis (Figure 2b).
Strikingly, enhancement of ATRA-induced differentiation was observed even when gefitinib was added as late as 24 h after initiation of ATRA treatment (data not shown), suggesting that inhibition of later or prolonged kinase signaling is important.
The combination of ATRA and gefitinib , however, yielded 41.7% CD11b positivity.
Leukemia  •  2008  |  View Paper