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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tretinoin
drug:
Fenretinide
Research Papers that Mention the Interaction
“Pre-treatment of neuroblastoma cell lines with retinoic acid RA ) resulted in a significant decrease in the apoptotic response to fenretinide in three of the four lines tested.”
“The interaction between RA and fenretinide could have important implications for the scheduling of fenretinide in therapeutic protocols for neuroblastoma.”
The impact of retinoic acid treatment on the sensitivity of neuroblastoma cells to fenretinide.“The levels of the retinoid receptors, retinoic acid receptor alpha and retinoid X receptor gamma, were up-regulated in response to fenretinide , suggestive of ligand-induced receptor up-regulation.”
“ N-(4-hydroxyphenyl) retinamide (Fenretinide, 4-HPR) inhibits cell growth by inducing apoptosis in numerous tumor cell types including all-trans-retinoic acid (ATRA)-resistant tumor cells.”
“After 30 minutes of RA and 4HPR (10(-7) mol/L) exposure, a 20% decrease of basal cAMP accumulation was seen, and forskolin cAMP-induced increase was abolished.”
“At 1.3 µM concentration (a clinically pharmacologically achievable dose), 4HPR increased ATRA sensitivity synergistically in HER2/neu-overexpressing BT-474, MDA-MB-453, and MCF-7/Her2 breast cancer cells.”
“Combining 4HPR with ATRA may lead to a novel, selective therapeutic or chemopreventive strategy against HER2/neu-overexpressing breast tumors.”
“ HPR exposure resulted in time-dependent increase in cellular metabolism of the retinoid as evidenced by increased formation of the inert metabolite N-(4-methoxyphenyl)-retinamide (MPR) and progressive increase in apoptosis.”
“We found that 4-hydroxyphenylretinamide (4-HPR) inhibited the catabolism of RA.”
“The antiproliferative effect of HPR was, in all cell lines except K422, more potent than that induced by an equimolar dose of all-trans retinoic acid (RA).”
“Abnormal retinal function has been reported in patients receiving the synthetic retinoid fenretinide.”
Fenretinide does not block visual pigment formation in the rat.“In addition, we have tested the hypothesis that vimentin expression after HPR and RA , taken as indirect evidence of the mechanisms of action of the two retinoids, may be different.”
N-(4-hydroxyphenyl)retinamide induces apoptosis in human leukemia hl-60 cells and mediates vimentin down-regulation.
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