Possible Interaction: Tretinoin and Doxorubicin Hydrochloride

“Addition of ATRA to ED may potentiate inflammation and contribute to TNBC regression.”

“Finally, the combined chemotherapy of doxorubicin and all-trans retinoic acid ( ATRA ) showed dramatically efficiency in suppressing HCC metastasis.”

“Co-treatment of the MDA-MB-231 cells with ATRA formulation and doxorubicin caused two-fold increase in the percentage of apoptosis (p<0.05).”

“In our previous study, we found that ATRA could alleviate glomerulosclerosis lesion in glomerulosclerosis rats induced by adriamycin.”

“A statistically significant reduction of these values was observed when 20 nM DOX was added to medium with E2 - 39.24 +/- 7.6%, TAM - 48.34 +/- 2.05% and ATRA - 21.98 +/- 1.69%, respectively; the percentage of PCNA- and Ki-67-positive cells was also reduced.”

“It was also shown that the effectiveness of DOX in combination with ATRA is significantly higher than that of DOX combined with TAM, which might suggest a valuable approach to the treatment of breast cancer.”

“The inhibitory effect was obtained when 20 nM of DOX and E2, TAM or ATRA were used simultaneously.”

“Differentiation of the cell lines SH-SY5Y and SMS-KCNR by RA abolished the cytotoxic effects of adriamycin ( Adr ) and cisplatin.”

“However, differentiation with all‐trans‐retinoic acid rendered the cells more resistant to adriamycin.”

“Corticosterone (CT), progesterone (PG), and retinoic acid (RA) are capable of inhibiting Doxorubicin (Dox) from inducing apoptosis in rat cardiomyocytes.”

“In our previous study, we found that ATRA could alleviate glomerulosclerosis lesion in glomerulosclerosis rats induced by adriamycin.”

“Adriamycin significantly inhibited the proliferation of MCF-7 cells (P < 0.01), and RA treatment further increased the cytotoxicity of adriamycin (P < 0.01) while oleamide and 18-α-GA obviously attenuated the cytotoxicity of adriamycin (P < 0.01).”