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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tretinoin
drug:
Deoxycholate
Research Papers that Mention the Interaction
“Combined administration of DCA and ATRA significantly reduced the labeling index of colon mucosa, which was increased by DCA, but did not affect the incidence of K‐ras point mutation in colon tumors.”
“Concomitant use of DCA and ATRA at either dose significantly attenuated the enhancement by DCA of colon tumorigenesis.”
“These findings suggest that DCA enhances development of colon tumors and that this enhancement is attenuated by ATRA.”
K‐ras point mutation is associated with enhancement by deoxycholic acid of colon carcinogenesis induced by azoxymethane, but not with its attenuation by all‐trans‐retinoic acid“ RA shares several characteristics of activation with sodium deoxycholate and arachidonic acid.”
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