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Discover Supplement-Drug Interactions

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Last Updated: 4 years ago

Possible Interaction: Tretinoin and Dasatinib

supplement:

Tretinoin

Research Papers that Mention the Interaction

Retinoids potentiated the activity of dasatinib in mouse and human BCR-ABL1 ALL, providing an additional therapeutic option in IKZF1-mutated ALL.
Cancer cell  •  2015  |  View Paper
In conclusion, the combination of dasatinib and ATRA could overcome ATRA resistance through Lyn inhibition-mediated activation of RAF-1/MEK/ERK.
In this study, dasatinib synergized with ATRA to trigger differentiation in ATRA-resistant APL cell lines.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2018  |  View Paper
Forced myeloid differentiation by all-trans-retinoic acid (ATRA) effectively blocked acquisition of BCR-ABL mutations and resistance to the TKIs imatinib, nilotinib or dasatinib in our previously described in vitro models of acquired TKI resistance.
PLoS genetics  •  2014  |  View Paper
In contrast another SFK inhibitor dasatinib ) which blocks Lyn activity with ATRA co-treatment prevented ATRA-induced c-Cbl phosphorylation and crippled p85 PI3K phosphorylation, indicating Lyn kinase activity is important for ATRA-propelled events potentially regulated by CD38.
Cellular signalling  •  2014  |  View Paper
Dasatinib inhibited the expression of phosphorylated Lyn, and further enhanced the differentiation-inducing activity of ATRA and VD3 in HL-60 cells.
Cancer Cell International  •  2016  |  View Paper