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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Tretinoin
drug:
Daratumumab
Research Papers that Mention the Interaction
“ All-trans retinoic acid increased CD38 levels and decreased CD55 and CD59 expression on MM cells from patients who developed daratumumab resistance, to approximately pretreatment values.”
CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma.“Lastly, we evaluate the impact of exposure to all-trans retinoic acid (ATRA) on wild type NK and CD38KO NK cells function and highlight potential benefit and drawbacks of combining ATRA with DARA in patients with MM.”
“Nijhof, I.S., Groen, R.W., Lokhorst, H.M., van Kessel, B., Bloem, A.C., van Velzen, J., de JongKorlaar, R., Yuan, ….C., Doshi, P., Sasser, K., Mutis, T. & van de Donk, N.W. (2015) Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid … daratumumab.”
“Here, we show that ATRA up-regulates CD38 expression on AML blasts to sufficient levels that promote antibody-mediated fratricide following the addition of anti-CD38 daratumumab (DARA).”
“The combination of ATRA plus DARA induced Fc-dependent conjugate formation and cytotoxicity among AML blasts in vitro.”
“Interestingly, all-trans retinoic acid treatment increased the inhibitory effect of Daratumumab on osteoclast formation.”
Expression of CD38 in myeloma bone niche: A rational basis for the use of anti-CD38 immunotherapy to inhibit osteoclast formation“Interestingly, all-trans retinoic acid treatment increased the inhibitory effect of Daratumumab on osteoclast formation.”
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