Possible Interaction: Tretinoin and Collagenases

“ Retinoic acid inhibits the enzyme collagenase by forming an inactive complex between the liganded nuclear retinoic acid receptors and c-Jun, a protein that is itself an activator of the collagenase gene.”

“The enhancement of collagenase mRNA levels was shown to be dependent on protein synthesis, and it could be counteracted by dexamethasone or all-trans-retinoic acid.”

“It has been observed that all-trans-retinoic acid and the synthetic retinoids could inhibit collagenase synthesis as successfully as the glucocorticoids.”

“The chapter discusses two classes of compounds that inhibit the synthesis of collagenase : the glucocorticoid hormones and the vitamin A analogs—that is, retinoids.”

“ Oral retinoids have been associated with suppression of collagenase , potentially causing excessive collagen accumulation and keloid formation, and possible atrophy of the pilosebaceous unit, where re-epithelialization for wound healing originates.”

“Comparative zymography clearly demonstrated the inhibitory effect of ATRA on collagenase enzyme activity.”

“In conclusion, our observations indicate that ATRA has an inhibitory effect on the expression of SiHa cell surface integrin receptors and collagenase enzyme activity.”

“Among its many pleiotropic effects, tretinoin is an established therapy for repair of dermal damage associated with photoaged … is partly restored by topical tretinoin use.6 In addition, more recent data provide solid evidence for tretinoin’… ( collagenase , stromelysin, gelatinase) after human skin injury … damage from another cause: excessive stretching.”

“ All‐trans retinoic acid (RA) decreased collagenase expression and stimulated TIMP‐1 expression.”

“We investigated the mechanism by which RA inhibits induction of collagenase gene transcription by inflammatory mediators, tumor promoters, and proto-oncogenes.”

“The apparent reduction of collagenase levels in the presence of RA , could result from a failure to accurately measure this enzyme in the presence of increased levels of TIMP.”

“Dexamethasone, colchicine or retinoic acid all inhibited collagenase synthesis by monocytes in a dose-dependent manner although the effect of these drugs on monocyte PGE2 synthesis differed.”