Possible Interaction: Tretinoin and Colforsin

“Co-treatment with gap junction enhancers such as all-trans retinoic acid (ATRA) and quinoline showed potentiating effects with FSK on cell survival via activation of cAMP/PKA/CREB.”

“In vivo, the combination of FSK and ATRA was more effective for preventing ototoxicity compared to either single treatment.”

“Growth inhibition by RA was further potentiated by forskolin (1 microM), an intracellular cyclic AMP-inducing agent.”

“Furthermore, RA inhibited forskolin and 8-Bromo-cyclic-AMP-induced TPO and Tg gene expression, suggesting a distal action site for these cAMP mediated gene expressions.”

“In response to forskolin , cAMP levels increased 30‐fold within 5 min, whereas a 10‐fold increase occurred 60 min following treatment with 10 μM retinoic acid.”

“However, when cells were treated with the differentiation-inducing agent retinoic acid, forskolin significantly promoted ES cell self-renewal.”

“ Retinoic acid inhibited the IL-6 synthesis induced by PGF2alpha or PGE1 in a dose-dependent manner in the range between 0.1 and 10 … synthesis stimulated by 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C. The IL-6 synthesis induced by cholera toxin, forskolin or ….”

“Time‐course studies indicated that RA elevated MMP‐2 activity levels in the cultures within 16 h. This increase was inhibited by cycloheximide and was enhanced by forskolin.”

“However, a combined treatment with t‐RA and forskolin , which activates adenylate cyclase, resulted in an additive increase in acetylcholine content.”

“On the other hand, RA significantly inhibited PGE2-induced cAMP accumulation in a dose-dependent manner between 0.1 … 0.1 microM. This effect of RA was dependent on the time of pretreatment up to 8 h. RA also inhibited the cAMP … by NaF or forskolin which directly … cyclase.”

“This effect is observed after incubation of the retinoid with dibutyryl cAMP, 8-bromo cAMP or forskolin.”