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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tretinoin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Furthermore, we also found overexpression of some genes in the same cell line (SK-N-BE(2) or SH-SY5Y) after combined treatment with both ATRA and CA , or ATRA and CX.”
Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: an expression profiling study“In addition, calcium and retinoids were shown to have profound influences on differentiation of epithelial cells (Hennings et al., 1980; Fuchs and Green, 1981).”
“The low calcium stimulated cell proliferation may also be inhibited by vitamin D and RA.”
“In additional studies it was shown that all-trans retinoic acid could overcome the known inhibitory effects of calcium on expression of HB-EGF-like growth factor mRNA in organ-cultured skin.”
“ Retinoic acid treatment caused a progressive and synchronous increase of the organ common‐type acylphosphatase and of free intracellular calcium but not of the muscle‐type acylphosphatase.”
“The same concentrations of RA that reduce the extracellular Ca2+ requirement also interrupt movement of Ca 2 + across the fibroblast plasma membrane.”
“Treatment of the cells with 3 micromol/L RA reduced membrane fluidity of the cells under both high- and low-Ca2+ conditions.”
“ Retinoic acid also stimulated transcription of beta 4 in tumor cells, but this was partially inhibited by the presence of high calcium.”
“We found that RA and the specific RA receptor (RAR) ligand Ch55 inhibited the phorbol ester and calcium ionophore-induced expression of the T-cell growth factor interleukin-2 (IL-2) gene.”
“Furthermore, addition of RA to cultures already exposed to higher Ca++ levels resulted in the complete loss of loricrin mRNA within 48-72 h. So far, no other components of the CE have been shown to be suppressed by RA.”
“ Retinoids also slightly inhibited intracellular calcium accumulation.”
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