“ Diethyl dithiocarbamate (DEDTC) has been reported to be a more powerful inhibitor of all-trans-retinoic acid (ATRA) in vitro metabolism than the well-established cytochrome P450 (CYP) inhibitor ketoconazole (KC).”
“It is concluded that the in vivo effect of CYP inhibitors DEDTC and KC) on the elimination rate of ATRA is qualitatively different from that expected from in vitro studies.”