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Last Updated: 2 years ago

Possible Interaction: Tretinoin and Caffeic Acid

supplement:

Tretinoin

supplement:

Caffeic Acid

Research Papers that Mention the Interaction

Furthermore, the extension of matrix mineralization was observed after combined treatment with ATRA and celecoxib or caffeic acid.
The results confirmed the capability of caffeic acid to enhance the antiproliferative effect of ATRA in both cell lines.
Tumor Biology  •  2014  |  View Paper
Our results showed that CA, in the concentration of 13 or 52 micro M, had no or minimal influence on cell differentiation, whereas the differentiating activity of ATRA was potentiated by CA treatment.
The possibility to enhance the differentiation potential of ATRA by CA may improve outcomes in the therapy of acute promyelocytic leukemia.
This effect was markedly enhanced when CA , at both concentrations, and ATRA were combined.
We investigated a possible enhancement of all-trans retinoic acid (ATRA)-induced differentiation of HL-60 human myeloid leukemia cells by caffeic acid (CA), a widely distributed plant phenolic compound.
We proved, using flow cytometric detection of the CD66b surface molecule, a synergistic effect of CA : at day 10, 18.3% of CD66b-positive cells were detected after treatment with ATRA only, and 33% when CA and ATRA were combined together.
International journal of molecular medicine  •  2004  |  View Paper
Although caffeic acid inhibited retinoic acid 5,6-epoxidation requiring the consumption of O2, formation of retinoic acid radicals was not inhibited on the addition of caffeic acid to the incubation mixture.
The above results suggest that caffeic acid does not inhibit the formation of retinoic acid radicals but does inhibit the step of conversion of retinoic acid radical into the 5,6-epoxide.
The Biochemical journal  •  1986  |  View Paper
The expression profiling was performed using Human Cancer Oligo GEArray membranes, and the most promising results were verified … RT-PCR.ResultsThe expression profiling of the selected cancer-related genes clearly confirmed that the differentiating effects of ATRA should be enhanced via its combined administration with caffeic acid or celecoxib.
Cancer Cell International  •  2014  |  View Paper