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Last Updated: 4 years ago

Possible Interaction: Tretinoin and Bortezomib

supplement:

Tretinoin

Research Papers that Mention the Interaction

Here, we show that bortezomib , the first proteasome inhibitor approved for newly diagnosed and relapsed multiple myeloma, exhibited strong synergism with ATRA to promote HL60 and NB4 AML cell differentiation.
Molecular Cancer Therapeutics  •  2012  |  View Paper
Bortezomib combined with ATRA had a significantly enhanced antiproliferative effect.
Here, we investigated the synergistic effect between bortezomib and ATRA in inducing NB cell differentiation in different NB cell lines.
The combination of bortezomib and ATRA triggered increased differentiation through the activation of proteins, including RARα, RARβ, RARγ, p-JNK and p21, compared with ATRA treatment alone.
Treatment of human NB cell CHP126-bearing nude mice with ATRA plus bortezomib resulted in more significant tumor growth inhibition than mice treated with either drug alone.
PloS one  •  2011  |  View Paper
Moreover, cell exposure to all-trans-Retinoic acid (ATRA, 3 μM) reduces the binding of Nrf2 to the ARE sequences, decreases HO-1 induction and lowers GSH level increasing the efficacy of bortezomib.
PloS one  •  2016  |  View Paper
Finally, the combination of all-trans-retinoic acid with bortezomib showed enhanced activity against primary patient samples and in a murine model of bortezomib-resistant myeloma.
The NRF2 inhibitor all-trans-retinoic acid reduced cellular NRF2 levels and increased the anti-proliferative and pro-apoptotic activities of bortezomib in resistant cells, while decreasing proteasome capacity.
The Journal of Biological Chemistry  •  2015  |  View Paper