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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Tretinoin
drug:
Belinostat
Research Papers that Mention the Interaction
“In addition, our study has shown that Belinostat and DZNep together with RA caused a depletion in HDAC1 and HDAC2 protein levels, HDAC2 gene expression and increased hyperacetylation of histone H4 in both leukemia cell lines.”
Anti‐leukemic effects of HDACi Belinostat and HMTi 3‐Deazaneplanocin A on human acute promyelocytic leukemia cells“Combined treatment with belinostat and RA dose dependently accelerated and reinforced granulocytic differentiation, accompanied by changes in the expression of CD11b, C/EBP&agr; (CCAAT/enhancer binding protein-&agr;), and C/EBP&egr;. Our results concluded the usefulness of belinostat, as an epigenetic drug, for antileukemia and differentiation therapy.”
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