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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Tretinoin
drug:
Becaplermin
Research Papers that Mention the Interaction
“Treatment of cells with trans-retinoic acid , an inhibitor of PDGF-BB activity, resulted in a 50% reduction in PDGF-BB-mediated induction and a concomitant block in the assembly of the proximal regulatory region.trans-Retinoic acid had minimal effect on TNF induction or promoter occupancy.”
trans-Retinoic Acid Blocks Platelet-derived Growth Factor-BB-induced Expression of the Murine Monocyte Chemoattractant-1 Gene by Blocking the Assembly of a Promoter Proximal Sp1 Binding Site*“The addition of both PDGF-BB and IGF II to QCE-6 cell cultures will inhibit the ability of retinoic acid , bFGF, TGF-beta 2, and TGF-beta 3 to induce both the mesenchymal morphology and QH1 and JB3 expression.”
“ ATRA could repress the PDGF-bb-induced excessive proliferation and migration of HUVSMCs, which was mediated by Rb-E2F dependent cell cycle inhibition.”
All-Trans Retinoic Acid Prevented Vein Grafts Stenosis by Inhibiting Rb-E2F Mediated Cell Cycle Progression and KLF5-RARα Interaction in Human Vein Smooth Muscle Cells
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