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“Furthermore, RA in combination with hydroquinone or 4‐hydroxyanisole, or azelaic acid increases the potency of depigmenting agents for the treatment of melasma, actinic lentigines, and postinflammatory hypermelanosis.”
“If use of a single agent does not lead to a good response, coupling the use of a retinoid with benzoyl peroxide or with azelaic acid can have a synergistic effect.”
The Western journal of medicine • 2000 | View Paper
“ Azelaic acid with tretinoin caused more skin lightening after three months than azelaic acid alone, and a higher proportion of excellent responders at the end of treatment.”
“ Tretinoin appears to enhance this effect of azelaic acid.”