Possible Interaction: Tretinoin and Arsenic Trioxide

“A group of 30 patients received ATO, and another group of 37 patients received ATO plus ATRA.”

“The largest difference, favoring patients treated with ATRA plus arsenic trioxide , was found for fatigue severity (mean score difference, -9.3; 95% CI, -17.8 to -0.7; P = .034) at end of induction therapy.”

“Our results suggest that the combination of As2O3 and ATRA might decrease the relapse rate compared with ATRA alone in induction therapy for childhood APL, at least in those with a WBC count less than 10 × 109/L.”

“ ATRA plus ATO may serve as an alternative to chemotherapy in low-risk untreated APL (eg, in older patients) and, when combined with GO, may improve outcome in high-risk patients.”

“Preclinical observations have indicated that all-trans-retinoic acid (ATRA) may strongly enhance the response to ATO.”

“ All-trans retinoic acid and arsenic trioxide , two widely used drugs in APL therapy, exert synergistic effects on controlling super-enhancer-associated PML/RARα-regulated targets in APL cells.”

“Strikingly, we demonstrate that the combination of ATRA and ATO proves to be a powerfully synergistic and effective therapy in a number of mouse and human mIDH1/2 leukemic models.”

“ ATRA increases cellular ATO uptake through upregulating aquaporin-9.”

“Here we show that ATO targets Pin1 and cooperates with ATRA to exert potent anticancer activity.”

“Compared with the historical 5-to 10-year survival rate of 10%, the survival of patients who undergo modern …%, and for specific subsets, the improvements are even more dramatic; for example, in acute promyelocytic leukemia, the use of all-trans retinoic acid … arsenic trioxide improved survival from … to 90%.”

“Moreover, addition of ATO , an agent that induces oxidative stress and interferes with protein translation, to ATRA sharply increases APL cell killing to the extent that cures in this disease are no longer unrealistic.”