Possible Interaction: Tretinoin and Acitretin

“The duration of treatment and total dose of retinoid required to achieve clearance were slightly lower in the calcipotriol + acitretin combination group, however, this was not statistically significant.”

“Several studies have confirmed that oral retinoids together with nbUVB (ReUVB) reduce the recovery time and also the doses of both acitretin and nbUVB.”

“Chemoprevention with the retinoid acitretin reduces the recurrence rate of SCC.”

“The aim of this study was to test the hypothesis that retinoids, such as acitretin , which bind preferentially to cellular retinoic acid binding proteins (CRABPs), or specific inhibitors of the RA hydroxylase CYP26, such as R116010, can increase the intracellular availability of ATRA.”

“ Retinoids significantly inhibited proliferation of certain SZ95 cell clones in the expected magnitude 13-cis-retinoic acid > all-trans-retinoic acid > > acitretin.”

“ Acitretin has therefore a great advantage with respect to the teratogenic potential of retinoids.”

“In the absence of viable fibroblasts, retinoic acid and isotretinoin increased epidermal growth, whereas etretin inhibited it.”

“In general, the retinoids inhibited proliferation; the action was cytostatic, in rank order tretinoin > isotretinoin > etretin > arotinoid.”

“ Acitretin displaces [3H]-all-trans-retinoic acid from the CRABPs and increases retinoic acid occupancy of the heterocomplexes.”