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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Trehalose
drug:
Uridine Triacetate
Research Papers that Mention the Interaction
“Cell treatment with trehalose could decrease cytosolic aggregates of potentially pathogenic proteins, including mutant huntingtin, α-synuclein, and phosphorylated tau that are associated with neurodegenerative diseases.”
Trehalose Alters Subcellular Trafficking and the Metabolism of the Alzheimer-associated Amyloid Precursor Protein*“We have recently shown that trehalose reduces tau pathology in a tauopathy mouse model by stimulation of autophagy.”
“Cotreatment with trehalose reduces the levels of β amyloid peptide aggregates, tau plaques and levels of phospho-tau.”
“Both rapamycin and trehalose significantly reduced TAU aggregation levels suggesting that iPSC-derived neurons allow for the generation of a biologically relevant human Tauopathy model, highly suitable to screen for compounds that modulate TAU aggregation.”
“In rat primary neurons, activation of autophagy by inhibition of proteasome activity or treatment with trehalose resulted in significant decreases in tau and phospho-tau levels.”
BAG3 facilitates the clearance of endogenous tau in primary neurons“Notably, apart from activating autophagy, trehalose also inhibits tau aggregation directly.”
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