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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Trehalose
drug:
Temozolomide
Research Papers that Mention the Interaction
“Along with a direct … mechanisms may explain how trehalose … TMZ‐ and IR‐induced effects: the remarkable trehalose‐stimulated autophagy in A375 cells, which were sensitive to TMZ‐ and IR‐induced … trehalose‐stimulated premature senescence in SK‐Mel‐28 cells, which were resistant to apoptosis and less prone to autophagy.”
“In long‐term experiments, colony‐forming capacity was dramatically reduced by trehalose , and even more by combined trehalose + TMZ or trehalose + IR.”
“We tested whether trehalose , a natural glucose disaccharide proved to induce autophagy, could enhance the effect of TMZ and ionizing radiation (IR).”
Trehalose inhibits cell proliferation and amplifies long‐term temozolomide‐ and radiation‐induced cytotoxicity in melanoma cells: A role for autophagy and premature senescence
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