Possible Interaction: Trazodone and Ginkgo Biloba Whole

“Clinical cases indicate interactions of ginkgo with antiepileptics, aspirin (acetylsalicylic acid), diuretics, ibuprofen, risperidone, rofecoxib, trazodone and warfarin.”

“According to a recent systematic review (2), four of the seven top-selling herbal medicines in this country interfere with the metabolism or efficacy of approved synthetic drugs: Ginkgo biloba (ginkgo) may enhance or alter the effects of warfarin, thiazide diuretics, and trazodone.”

“We describe a patient with Alzheimer's disease who developed coma a few days after starting low dose trazodone associated with ginkgo biloba.”

“Similarly, case reports have demonstrated that ginkgo may potentiate bleeding when combined with warfarin or aspirin, increases blood pressure when combined with thiazide diuretics, and has even led to a coma when combined with trazodone , a serotonin antagonist and reuptake inhibitor used to treat depression.”