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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Yohimbine significantly reversed the … effects of tramadol for 2.8 h with a maximum decrease of 97 +/- 4% (RIII) and 67 +/- 12% (PINS), whereas the addition of naloxone abolished tramadol effects throughout the study period with a decrease of 90 +/- 6% (RIII) and 79 +/- 9% (PINS), P < 0.05).”
Contribution of monoaminergic modulation to the analgesic effect of tramadol.“Furthermore, tramadol inhibited the nerve ligation-induced activation of spinal astrocytes, which was reduced by yohimbine.”
“Like amitriptyline, repeated administration of tramadol showed preventive and alleviative effects on the mechanical allodynia that was diminished by yohimbine , but not naloxone.”
“The alleviative effects of tramadol lasted even after drug cessation or in the presence of yohimbine.”
Preventive and alleviative effect of tramadol on neuropathic pain in rats: roles of α₂-adrenoceptors and spinal astrocytes.“In addition, the effect of tramadol at this later time point could be reduced with yohimbine as well as naloxone.”
“The possibility that this additional activity contributes to the antinociceptive activity of tramadol was supported by the finding that systemically administered yohimbine or ritanserin blocked the antinociception produced by intrathecal administration of tramadol , but not morphine, in the rat tail-flick test.”
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