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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Topiramate
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Five days after initiation of topiramate , mean calcium decreased to 211.5 mg/day (31% decrease), and mean citrate decreased to 398 (99 to 804) mg/day, an average decrease of 39.8% (6.5% to 65.9%) per patient.”
Induction of progressive profound hypocitraturia with increasing doses of topiramate.“It has been proved that topiramate also inhibits lipogenesis in adipocytes, similarly to other sulfonamide CA inhibitors investigated earlier.”
“Conclusion: The two doses of TOP modulated MMCA activity, total brain cortex calcium and hippocampus NMDAR 2A and 2B subunit concentrations in the epileptic rats.”
Topiramate modulates hippocampus NMDA receptors via brain Ca2+ homeostasis in pentylentetrazol-induced epilepsy of rats
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