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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Tolbutamide
supplement:
Trypsin
Research Papers that Mention the Interaction
“The protease also reduced the inhibitory effect of ATP on channel activity, increasing the dissociation constant from 7 to 49 microM. Trypsin removed the activating effect of ADP (0.1 mmol/l) on channel activity and reduced the inhibitory effect of tolbutamide (0.5 mmol/l).”
Modification of K-ATP channels in pancreatic beta-cells by trypsin.
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