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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Tolbutamide
supplement:
St John's Wort
Research Papers that Mention the Interaction
“ St. John's wort administration affected CYP activity, causing a significant decline in AUC of dextromethorphan [F(4,31)=1511, p<0.001; PLSD, … midazolam [F(3,25)=221, p<0.001; PLSD, p=0.035] and a significant increase in AUC of tolbutamide [F(3,26)=…<0.001].”
Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver.
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