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Last Updated: 2 months ago

Possible Interaction: Tolbutamide and Ginkgo Biloba Whole

Research Papers that Mention the Interaction

Concomitantly, GBE tended to attenuate AUC0-2 of blood glucose-lowering effect of tolbutamide.
The area under concentration versus time curve (AUC0-infinity) for tolbutamide after GBE intake was slightly but significantly (16%) lower than that before GBE intake.
Journal of clinical pharmacology  •  2006  |  View Paper
Ginkgo (Ginkgo biloba) decreases the plasma concentrations of omeprazole, ritonavir and tolbutamide.
Drugs  •  2012  |  View Paper
Ginkgo biloba L. induces both CYP3A4 and CYP2C9 and alters the AUC and Cmax of conventional medications including midazolam, tolbutamide , lopinavir and nifedipine.
Current topics in medicinal chemistry  •  2019  |  View Paper
Further, the pretreatment of GBE significantly attenuated the hypoglycemic action of tolbutamide in the aged rats, corresponding well to the enhanced activity of (S)-warfarin 7-hydroxylase, which is responsible for CYP2C9 subtype, a major isoform metabolizing tolbutamide.
In conclusion, the present study has shown that the simultaneous and continuous intake of GBE significantly affects the hypoglycemic action of tolbutamide , possibly via a hepatic CYP enzyme-mediated mechanism, particularly in the aged rats.
In contrast, the simultaneous administration of GBE with tolbutamide potentiated the hypoglycemic action of this drug.
In the young rats, the 5 day pretreatment with GBE significantly attenuated the hypoglycemic action of tolbutamide , but a simultaneous treatment had little influence on the tolbutamide effect.
Life sciences  •  2004  |  View Paper