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Last Updated: 3 years ago
drug:
Tolbutamide
supplement:
Ginkgo Biloba Whole
Research Papers that Mention the Interaction
“Concomitantly, GBE tended to attenuate AUC0–2 of blood glucose—lowering effect of tolbutamide.”
“The area under concentration versus time curve (AUC0–∞) for tolbutamide after GBE intake was slightly but significantly (16%) lower than that before GBE intake.”
Effects of Ginkgo Biloba Extract on Pharmacokinetics and Pharmacodynamics of Tolbutamide and Midazolam in Healthy Volunteers“Further, the pretreatment of GBE significantly attenuated the hypoglycemic action of tolbutamide in the aged rats, corresponding well to the enhanced activity of (S)-warfarin 7-hydroxylase, which is responsible for CYP2C9 subtype, a major isoform metabolizing tolbutamide.”
“In conclusion, the present study has shown that the simultaneous and continuous intake of GBE significantly affects the hypoglycemic action of tolbutamide , possibly via a hepatic CYP enzyme-mediated mechanism, particularly in the aged rats.”
“In contrast, the simultaneous administration of GBE with tolbutamide potentiated the hypoglycemic action of this drug.”
“In the young rats, the 5 day pretreatment with GBE significantly attenuated the hypoglycemic action of tolbutamide , but a simultaneous treatment had little influence on the tolbutamide effect.”
“The in vitro experiments revealed that GBE competitively inhibited the metabolism of tolbutamide by (S)-warfarin 7-hydroxylase in the rat liver microsomes.”
Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats.
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