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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Tolbutamide and Ginkgo Biloba Whole

Research Papers that Mention the Interaction

Concomitantly, GBE tended to attenuate AUC0–2 of blood glucose—lowering effect of tolbutamide.
The area under concentration versus time curve (AUC0–∞) for tolbutamide after GBE intake was slightly but significantly (16%) lower than that before GBE intake.
Journal of clinical pharmacology  •  2006  |  View Paper
Further, the pretreatment of GBE significantly attenuated the hypoglycemic action of tolbutamide in the aged rats, corresponding well to the enhanced activity of (S)-warfarin 7-hydroxylase, which is responsible for CYP2C9 subtype, a major isoform metabolizing tolbutamide.
In conclusion, the present study has shown that the simultaneous and continuous intake of GBE significantly affects the hypoglycemic action of tolbutamide , possibly via a hepatic CYP enzyme-mediated mechanism, particularly in the aged rats.
In contrast, the simultaneous administration of GBE with tolbutamide potentiated the hypoglycemic action of this drug.
In the young rats, the 5 day pretreatment with GBE significantly attenuated the hypoglycemic action of tolbutamide , but a simultaneous treatment had little influence on the tolbutamide effect.
The in vitro experiments revealed that GBE competitively inhibited the metabolism of tolbutamide by (S)-warfarin 7-hydroxylase in the rat liver microsomes.
Life sciences  •  2004  |  View Paper